5-Fluorouracil Derivatives. I. The Synthesis of 1-Carbamoyl-5-fluorouracils
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چکیده
منابع مشابه
Synthesis and bioevaluation of 5-fluorouracil derivatives.
A series of six novel 5-fluorouracil derivatives 1-6 were synthesized and their structures confirmed by (1)H- and (13)C-NMR, MS and elemental analysis. The preliminary in vitro antitumor activities against B16, K562 and CHO cells and the in vivo inhibitions of liver cancer H(22) demonstrated that some of these compounds effectively inhibit the growth of tumor cells, but the in vivo trials in mi...
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Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
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Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits. Plasma concentration of both 5-FU and its metabolit...
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Primary and secondary phosphine complexes are convenient precursors of terminal phosphido-metal compounds by deprotonation. Recent work has shown that the chiral tertiary phosphido-metal group Fe —PMePh can be generated stereospecifically by deprotonation of a resolved secondary phosphine complex at —90 °C, and, furthermore, that it can be alkylated with retention of configuration and com plet...
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New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the con...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1977
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.50.2406